Transforming Growth Factor β Engages TACE and ErbB3 To Activate Phosphatidylinositol-3 Kinase/Akt in ErbB2-Overexpressing Breast Cancer and Desensitizes Cells to Trastuzumab

In HER2-overexpressing mammary epithelial cells, transforming growth factor β (TGF-β) activated phosphatidylinositol-3 kinase (PI3K)/Akt and enhanced survival and migration. Treatment with TGF-β or expression of an activated TGF-β type I receptor (Alk5 with the mutation T204D [Alk5(T204D)]) induced...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Wang, Shizhen Emily, Xiang, Bin, Guix, Marta, Olivares, Maria Graciela, Parker, Joel, Chung, Christine H., Pandiella, Atanasio, Arteaga, Carlos L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2546920/
https://ncbi.nlm.nih.gov/pubmed/18625725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00787-08
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky