Human pancreatic cancer stem cells are sensitive to dual inhibition of IGF-IR and ErbB receptors

BACKGROUND: Pancreatic ductal adenocarcinoma is a particularly challenging malignancy characterized by poor responsiveness to conventional chemotherapy. Although this tumor frequently overexpresses or possesses constitutively activated variants of IGF-IR and EGFR/Her-2, clinical trials using inhibit...

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Bibliographic Details
Published in:BMC Cancer
Main Authors: Urtasun, Nerea, Vidal-Pla, Anna, Pérez-Torras, Sandra, Mazo, Adela
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403908/
https://ncbi.nlm.nih.gov/pubmed/25886138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1249-2
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