Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication

Mammalian telomeres are associated with shelterin, the telomere specific protein complex that solves the end-protection problem. The telomeric shelterin binding sites, TTAGGG repeats, are maintained by telomerase, which solves the end-replication problem. We report that the TTAGGG repeat arrays of h...

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Bibliografske podrobnosti
Main Authors: Sfeir, Agnel, Kosiyatrakul, Settapong T., Hockemeyer, Dirk, MacRae, Sheila L., Karlseder, Jan, Schildkraut, Carl L., de Lange, Titia
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2723738/
https://ncbi.nlm.nih.gov/pubmed/19596237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.06.021
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