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Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging
The tumor suppressors p16(INK4a) and p53 have been implicated as contributors to age-associated stem cell decline. Key functions of p53 are the induction of cell cycle arrest, senescence, or apoptosis in response to DNA damage. Here, we examine senescence, apoptosis, and DNA damage responses in a mo...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2722837/ https://ncbi.nlm.nih.gov/pubmed/19396980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2009.01.001 |
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