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How does suppression of IGF-1 signaling by DNA damage affect aging and longevity?
Long-lived animals have evolved a robust set of defenses to maintain genomic integrity over their entire lifespan. The DNA damage response and DNA repair pathways are critical pillars of organismal defenses, minimizing somatic mutations in both post-mitotic and mitotic cells. These genomic maintenan...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2396493/ https://ncbi.nlm.nih.gov/pubmed/18374391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2008.02.005 |
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