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How does suppression of IGF-1 signaling by DNA damage affect aging and longevity?

Long-lived animals have evolved a robust set of defenses to maintain genomic integrity over their entire lifespan. The DNA damage response and DNA repair pathways are critical pillars of organismal defenses, minimizing somatic mutations in both post-mitotic and mitotic cells. These genomic maintenan...

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Detalhes bibliográficos
Main Authors: Hinkal, George, Donehower, Lawrence A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396493/
https://ncbi.nlm.nih.gov/pubmed/18374391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2008.02.005
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