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Using Mice to Examine p53 Functions in Cancer, Aging, and Longevity

The p53 tumor suppressor is a multifaceted transcription factor that responds to a diverse array of stresses that include DNA damage and aberrant oncogene signaling. On activation, p53 prevents the emergence of cancer cells by initiating cell cycle arrest, senescence (terminal cell cycle arrest), or...

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Détails bibliographiques
Auteur principal: Donehower, Lawrence A.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882127/
https://ncbi.nlm.nih.gov/pubmed/20457560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a001081
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