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DIRECT TARGETING OF THE MUC1 ONCOPROTEIN BLOCKS SURVIVAL AND TUMORIGENICITY OF HUMAN BREAST CARCINOMA CELLS
The MUC1 oncoprotein is aberrantly overexpressed by approximately 90% of human breast cancers. However, there are no effective agents that directly inhibit MUC1 and induce death of breast cancer cells. We have synthesized a MUC1 inhibitor, designated GO-201, that binds to the MUC1 cytoplasmic domain...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2721222/ https://ncbi.nlm.nih.gov/pubmed/19491255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0854 |
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