DIRECT TARGETING OF THE MUC1 ONCOPROTEIN BLOCKS SURVIVAL AND TUMORIGENICITY OF HUMAN BREAST CARCINOMA CELLS

The MUC1 oncoprotein is aberrantly overexpressed by approximately 90% of human breast cancers. However, there are no effective agents that directly inhibit MUC1 and induce death of breast cancer cells. We have synthesized a MUC1 inhibitor, designated GO-201, that binds to the MUC1 cytoplasmic domain...

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Detalhes bibliográficos
Main Authors: Raina, Deepak, Ahmad, Rehan, Joshi, Maya Datt, Yin, Li, Wu, Zekui, Kawano, Takeshi, Vasir, Baldev, Avigan, David, Kharbanda, Surender, Kufe, Donald
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721222/
https://ncbi.nlm.nih.gov/pubmed/19491255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0854
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