MUC1-C ONCOPROTEIN FUNCTIONS AS A DIRECT ACTIVATOR OF THE NF-κB p65 TRANSCRIPTION FACTOR

Nuclear factor-κB (NF-κB) is constitutively activated in diverse human malignancies. The MUC1 oncoprotein is overexpressed in human carcinomas and, like NF-κB, blocks cell death and induces transformation. The present studies demonstrate that MUC1 constitutively associates with NF-κB p65 in carcinom...

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Hauptverfasser: Ahmad, Rehan, Raina, Deepak, Joshi, Maya Datt, Kawano, Takeshi, Ren, Jian, Kharbanda, Surender, Kufe, Donald
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760979/
https://ncbi.nlm.nih.gov/pubmed/19706766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0523
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