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MUC1 ONCOPROTEIN BLOCKS DEATH RECEPTOR-MEDIATED APOPTOSIS BY INHIBITING RECRUITMENT OF CASPASE-8
Stimulation of the death receptor superfamily induces the activation of caspase-8 and thereby the apoptotic response. The MUC1 oncoprotein is aberrantly overexpressed by diverse human malignancies and inhibits stress-induced apoptosis. The present results demonstrate that MUC1 blocks activation of c...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2536759/ https://ncbi.nlm.nih.gov/pubmed/18676836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0464 |
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