MUC1 ONCOPROTEIN BLOCKS DEATH RECEPTOR-MEDIATED APOPTOSIS BY INHIBITING RECRUITMENT OF CASPASE-8

Stimulation of the death receptor superfamily induces the activation of caspase-8 and thereby the apoptotic response. The MUC1 oncoprotein is aberrantly overexpressed by diverse human malignancies and inhibits stress-induced apoptosis. The present results demonstrate that MUC1 blocks activation of c...

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Hlavní autoři: Agata, Naoki, Ahmad, Rehan, Kawano, Takeshi, Raina, Deepak, Kharbanda, Surender, Kufe, Donald
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2536759/
https://ncbi.nlm.nih.gov/pubmed/18676836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0464
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