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Targeting cysteine-mediated dimerization of the MUC1-C oncoprotein in human cancer cells
The MUC1 heterodimeric protein is aberrantly overexpressed in diverse human carcinomas and contributes to the malignant phenotype. The MUC1-C transmembrane subunit contains a CQC motif in the cytoplasmic domain that has been implicated in the formation of dimers and in its oncogenic function. The pr...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3326351/ https://ncbi.nlm.nih.gov/pubmed/22200620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2011.1308 |
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