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Targeting cysteine-mediated dimerization of the MUC1-C oncoprotein in human cancer cells
The MUC1 heterodimeric protein is aberrantly overexpressed in diverse human carcinomas and contributes to the malignant phenotype. The MUC1-C transmembrane subunit contains a CQC motif in the cytoplasmic domain that has been implicated in the formation of dimers and in its oncogenic function. The pr...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3326351/ https://ncbi.nlm.nih.gov/pubmed/22200620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2011.1308 |
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