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MUC1-C Oncoprotein Promotes STAT3 Activation in an Autoinductive Regulatory Loop

Signal transducer and activator of transcription 3 (STAT3) is activated in human breast cancer and other malignancies. Mucin 1 (MUC1) is a heterodimeric cell surface glycoprotein that is overexpressed in human carcinomas and, like STAT3, promotes cell survival and induces transformation. Here, we sh...

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Detalhes bibliográficos
Main Authors: Ahmad, Rehan, Rajabi, Hasan, Kosugi, Michio, Joshi, Maya Datt, Alam, Maroof, Vasir, Baldev, Kawano, Takeshi, Kharbanda, Surender, Kufe, Donald
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070357/
https://ncbi.nlm.nih.gov/pubmed/21325207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001426
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