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Crystal Structures of Fe(2+) Dioxygenase Superoxo, Alkylperoxo, and Bound Product Intermediates

We report the structures of three intermediates in the O(2) activation and insertion reactions of an extradiol ring-cleaving dioxygenase. A crystal of Fe(2+)-containing homoprotocatechuate 2,3-dioxygenase was soaked in the slow substrate 4-nitrocatechol in a low O(2) atmosphere. The X-ray crystal st...

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Detalles Bibliográficos
Main Authors: Kovaleva, Elena G., Lipscomb, John D.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720167/
https://ncbi.nlm.nih.gov/pubmed/17446402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1134697
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