Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs

Release of hemoglobin (Hb) into the circulation is a central pathophysiologic event that contributes to morbidity and mortality in chronic hemolytic anemias and severe malaria. These toxicities arise from Hb-mediated vasoactivity, possibly due to NO scavenging and localized tissue oxidative processe...

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Detalhes bibliográficos
Main Authors: Boretti, Felicitas S., Buehler, Paul W., D’Agnillo, Felice, Kluge, Katharina, Glaus, Tony, Butt, Omer I., Jia, Yiping, Goede, Jeroen, Pereira, Claudia P., Maggiorini, Marco, Schoedon, Gabriele, Alayash, Abdu I., Schaer, Dominik J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719941/
https://ncbi.nlm.nih.gov/pubmed/19620788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39115
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