Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species–pharmacokinetic and therapeutic implications

Background: Haptoglobin (Hp) prevents hemoglobin (Hb) extravasation and attenuates Hb induced tissue oxidation and vasoconstriction. Small animal models such as mouse, rat and guinea pig appear to demonstrate proof-of-concept for Hb neutralization by Hp in diverse pre-clinical conditions. However, t...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Boretti, Felicitas S., Baek, Jin Hyen, Palmer, Andre F., Schaer, Dominik J., Buehler, Paul W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2014
Ämnen:
Physiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191077/
https://ncbi.nlm.nih.gov/pubmed/25346694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2014.00385
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