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Apohemoglobin-haptoglobin complex attenuates the pathobiology of circulating acellular hemoglobin and heme
Haptoglobin (Hp) is the plasma protein that binds and clears cell-free hemoglobin (Hb), whereas apohemoglobin (apoHb, i.e., Hb devoid of heme) can bind heme. Therefore, the apoHb-Hp protein complex should facilitate holoHb-apoHb αβ-dimer exchange and apoHb-heme intercalation. Thus, we hypothesized t...
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| Publicat a: | Am J Physiol Heart Circ Physiol |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Physiological Society
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7346542/ https://ncbi.nlm.nih.gov/pubmed/32302494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00136.2020 |
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