Apohemoglobin-haptoglobin complex attenuates the pathobiology of circulating acellular hemoglobin and heme

Haptoglobin (Hp) is the plasma protein that binds and clears cell-free hemoglobin (Hb), whereas apohemoglobin (apoHb, i.e., Hb devoid of heme) can bind heme. Therefore, the apoHb-Hp protein complex should facilitate holoHb-apoHb αβ-dimer exchange and apoHb-heme intercalation. Thus, we hypothesized t...

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Bibliographic Details
Published in:Am J Physiol Heart Circ Physiol
Main Authors: Munoz, Carlos J., Pires, Ivan S., Baek, Jin Hyen, Buehler, Paul W., Palmer, Andre F., Cabrales, Pedro
Format: Artigo
Language:Inglês
Published: American Physiological Society 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7346542/
https://ncbi.nlm.nih.gov/pubmed/32302494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00136.2020
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