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Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy

Massive transfusion of blood can lead to clinical complications, including multiorgan dysfunction and even death. Such severe clinical outcomes have been associated with longer red blood cell (rbc) storage times. Collectively referred to as the rbc storage lesion, rbc storage results in multiple bio...

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Detalhes bibliográficos
Main Authors: Baek, Jin Hyen, D’Agnillo, Felice, Vallelian, Florence, Pereira, Claudia P., Williams, Matthew C., Jia, Yiping, Schaer, Dominik J., Buehler, Paul W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314461/
https://ncbi.nlm.nih.gov/pubmed/22446185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59770
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