Prolylcarboxypeptidase regulates food intake by inactivating α-MSH in rodents

The anorexigenic neuromodulator α-melanocyte–stimulating hormone (α-MSH; referred to here as α-MSH(1–13)) undergoes extensive posttranslational processing, and its in vivo activity is short lived due to rapid inactivation. The enzymatic control of α-MSH(1–13) maturation and inactivation is incomplet...

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Main Authors: Wallingford, Nicholas, Perroud, Bertrand, Gao, Qian, Coppola, Anna, Gyengesi, Erika, Liu, Zhong-Wu, Gao, Xiao-Bing, Diament, Adam, Haus, Kari A., Shariat-Madar, Zia, Mahdi, Fakhri, Wardlaw, Sharon L., Schmaier, Alvin H., Warden, Craig H., Diano, Sabrina
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719925/
https://ncbi.nlm.nih.gov/pubmed/19620781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37209
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