The Functional Roles of the His(247) and His(281) Residues in Folate and Proton Translocation Mediated by the Human Proton-coupled Folate Transporter SLC46A1

This report addresses the functional role of His residues in the proton-coupled folate transporter (PCFT; SLC46A1), which mediates intestinal folate absorption. Of ten His residues, only H247A and H281A mutations altered function. The folic acid influx K(t) at pH 5.5 for H247A was ↓8.4-fold. Althoug...

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Bibliographic Details
Main Authors: Unal, Ersin Selcuk, Zhao, Rongbao, Chang, Min-Hwang, Fiser, Andras, Romero, Michael F., Goldman, I. David
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Membrane Transport, Structure, Function, and Biogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719423/
https://ncbi.nlm.nih.gov/pubmed/19389703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.008060
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