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The Functional Roles of the His(247) and His(281) Residues in Folate and Proton Translocation Mediated by the Human Proton-coupled Folate Transporter SLC46A1
This report addresses the functional role of His residues in the proton-coupled folate transporter (PCFT; SLC46A1), which mediates intestinal folate absorption. Of ten His residues, only H247A and H281A mutations altered function. The folic acid influx K(t) at pH 5.5 for H247A was ↓8.4-fold. Althoug...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2719423/ https://ncbi.nlm.nih.gov/pubmed/19389703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.008060 |
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