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Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding

The proton-coupled folate transporter (PCFT-SLC46A1) is required for intestinal folate absorption and folate transport across the choroid plexus. This report addresses the structure/function of the 8(th) transmembrane helix. Based upon biotinylation of cysteine-substituted residues by MTSEA-biotin,...

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Veröffentlicht in:Biochim Biophys Acta
Hauptverfasser: Aluri, Srinivas, Zhao, Rongbao, Fiser, Andras, Goldman, I David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5624325/
https://ncbi.nlm.nih.gov/pubmed/28802835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2017.08.006
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