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Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding
The proton-coupled folate transporter (PCFT-SLC46A1) is required for intestinal folate absorption and folate transport across the choroid plexus. This report addresses the structure/function of the 8(th) transmembrane helix. Based upon biotinylation of cysteine-substituted residues by MTSEA-biotin,...
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| Publicado no: | Biochim Biophys Acta |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5624325/ https://ncbi.nlm.nih.gov/pubmed/28802835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2017.08.006 |
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