Boosting Antimicrobial Peptides by Hydrophobic Oligopeptide End Tags

A novel approach for boosting antimicrobial peptides through end tagging with hydrophobic oligopeptide stretches is demonstrated. Focusing on two peptides derived from kininogen, GKHKNKGKKNGKHNGWK (GKH17) and HKHGHGHGKHKNKGKKN (HKH17), tagging resulted in enhanced killing of Gram-positive Staphyloco...

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Detalhes bibliográficos
Main Authors: Schmidtchen, Artur, Pasupuleti, Mukesh, Mörgelin, Matthias, Davoudi, Mina, Alenfall, Jan, Chalupka, Anna, Malmsten, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Genomics, Proteomics, and Bioinformatics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719397/
https://ncbi.nlm.nih.gov/pubmed/19398550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.011650
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