Boosting Antimicrobial Peptides by Hydrophobic Oligopeptide End Tags

A novel approach for boosting antimicrobial peptides through end tagging with hydrophobic oligopeptide stretches is demonstrated. Focusing on two peptides derived from kininogen, GKHKNKGKKNGKHNGWK (GKH17) and HKHGHGHGKHKNKGKKN (HKH17), tagging resulted in enhanced killing of Gram-positive Staphyloco...

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Bibliografiske detaljer
Main Authors: Schmidtchen, Artur, Pasupuleti, Mukesh, Mörgelin, Matthias, Davoudi, Mina, Alenfall, Jan, Chalupka, Anna, Malmsten, Martin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Genomics, Proteomics, and Bioinformatics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719397/
https://ncbi.nlm.nih.gov/pubmed/19398550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.011650
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