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Evaluation of Strategies for Improving Proteolytic Resistance of Antimicrobial Peptides by Using Variants of EFK17, an Internal Segment of LL-37

Methods for increasing the proteolytic stability of EFK17 (EFKRIVQRIKDFLRNLV), a new peptide sequence with antimicrobial properties derived from LL-37, were evaluated. EFK17 was modified by four d-enantiomer or tryptophan (W) substitutions at known protease cleavage sites as well as by terminal amid...

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מידע ביבליוגרפי
Main Authors: Strömstedt, Adam A., Pasupuleti, Mukesh, Schmidtchen, Artur, Malmsten, Martin
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology (ASM) 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630634/
https://ncbi.nlm.nih.gov/pubmed/19029324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00477-08
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