Boosting Antimicrobial Peptides by Hydrophobic Oligopeptide End Tags

A novel approach for boosting antimicrobial peptides through end tagging with hydrophobic oligopeptide stretches is demonstrated. Focusing on two peptides derived from kininogen, GKHKNKGKKNGKHNGWK (GKH17) and HKHGHGHGKHKNKGKKN (HKH17), tagging resulted in enhanced killing of Gram-positive Staphyloco...

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Hlavní autoři: Schmidtchen, Artur, Pasupuleti, Mukesh, Mörgelin, Matthias, Davoudi, Mina, Alenfall, Jan, Chalupka, Anna, Malmsten, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Genomics, Proteomics, and Bioinformatics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719397/
https://ncbi.nlm.nih.gov/pubmed/19398550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.011650
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