Loss of Wip1 Sensitizes Cells to Stress- and DNA Damage-induced Apoptosis

In response to various environmental stresses, the stress-responsive MAPKs p38 and JNK are activated and phosphorylate ATF2 and c-Jun transcription factors, thereby affecting cell-fate decision. Targeted gene disruption studies have established that JNK-c-Jun signaling plays a vital role in stress-i...

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Bibliographic Details
Main Authors: Xia, Yun, Ongusaha, Pat, Lee, Sam W., Liou, Yih-Cherng
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719383/
https://ncbi.nlm.nih.gov/pubmed/19395378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.007823
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