Loss of SOD1 and LYS7 Sensitizes Saccharomyces cerevisiae to Hydroxyurea and DNA Damage Agents and Downregulates MEC1 Pathway Effectors

Aerobic metabolism produces reactive oxygen species, including superoxide anions, which cause DNA damage unless removed by scavengers such as superoxide dismutases. We show that loss of the Cu,Zn-dependent superoxide dismutase, SOD1, or its copper chaperone, LYS7, confers oxygen-dependent sensitivit...

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Autori principali: Carter, Carole D., Kitchen, Lauren E., Au, Wei-Chun, Babic, Christopher M., Basrai, Munira A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1291217/
https://ncbi.nlm.nih.gov/pubmed/16287844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.23.10273-10285.2005
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