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Loss of Wip1 Sensitizes Cells to Stress- and DNA Damage-induced Apoptosis
In response to various environmental stresses, the stress-responsive MAPKs p38 and JNK are activated and phosphorylate ATF2 and c-Jun transcription factors, thereby affecting cell-fate decision. Targeted gene disruption studies have established that JNK-c-Jun signaling plays a vital role in stress-i...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2719383/ https://ncbi.nlm.nih.gov/pubmed/19395378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.007823 |
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