The External Aldimine Form of Serine Palmitoyltransferase: STRUCTURAL, KINETIC, AND SPECTROSCOPIC ANALYSIS OF THE WILD-TYPE ENZYME AND HSAN1 MUTANT MIMICS

Sphingolipid biosynthesis begins with the condensation of l-serine and palmitoyl-CoA catalyzed by the PLP-dependent enzyme serine palmitoyltransferase (SPT). Mutations in human SPT cause hereditary sensory autonomic neuropathy type 1, a disease characterized by loss of feeling in extremities and sev...

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Bibliographic Details
Main Authors: Raman, Marine C. C., Johnson, Kenneth A., Yard, Beverley A., Lowther, Jonathan, Carter, Lester G., Naismith, James H., Campopiano, Dominic J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Enzyme Catalysis and Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719368/
https://ncbi.nlm.nih.gov/pubmed/19376777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.008680
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