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Use of isotopically labeled substrates reveals kinetic differences between human and bacterial serine palmitoyltransferase

Isotope labels are frequently used tools to track metabolites through complex biochemical pathways and to discern the mechanisms of enzyme-catalyzed reactions. Isotopically labeled l-serine is often used to monitor the activity of the first enzyme in sphingolipid biosynthesis, serine palmitoyltransf...

詳細記述

保存先:
書誌詳細
出版年:J Lipid Res
主要な著者: Harrison, Peter J., Gable, Kenneth, Somashekarappa, Niranjanakumari, Kelly, Van, Clarke, David J., Naismith, James H., Dunn, Teresa M., Campopiano, Dominic J.
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Biochemistry and Molecular Biology 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6495160/
https://ncbi.nlm.nih.gov/pubmed/30792183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M089367
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