The L84F polymorphic variant of human O(6)-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity

First-line therapy for patients with glioblastoma multiforme includes treatment with radiation and temozolomide (TMZ), an oral DNA alkylating chemotherapy. Sensitivity of glioma cells to TMZ is dependent on the level of cellular O(6)-methylguanine-DNA methyltransferase (MGMT) repair activity. Severa...

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Autores principales: Remington, Maya, Chtchetinin, Jana, Ancheta, Karen, Nghiemphu, Phioanh Leia, Cloughesy, Timothy, Lai, Albert
Formato: Artigo
Lenguaje:Inglês
Publicado: Duke University Press 2009
Materias:
Basic and Translational Investigations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718956/
https://ncbi.nlm.nih.gov/pubmed/18812520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2008-080
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