The L84F polymorphic variant of human O(6)-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity

First-line therapy for patients with glioblastoma multiforme includes treatment with radiation and temozolomide (TMZ), an oral DNA alkylating chemotherapy. Sensitivity of glioma cells to TMZ is dependent on the level of cellular O(6)-methylguanine-DNA methyltransferase (MGMT) repair activity. Severa...

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Hlavní autoři: Remington, Maya, Chtchetinin, Jana, Ancheta, Karen, Nghiemphu, Phioanh Leia, Cloughesy, Timothy, Lai, Albert
Médium: Artigo
Jazyk:Inglês
Vydáno: Duke University Press 2009
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718956/
https://ncbi.nlm.nih.gov/pubmed/18812520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2008-080
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