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The L84F polymorphic variant of human O(6)-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity
First-line therapy for patients with glioblastoma multiforme includes treatment with radiation and temozolomide (TMZ), an oral DNA alkylating chemotherapy. Sensitivity of glioma cells to TMZ is dependent on the level of cellular O(6)-methylguanine-DNA methyltransferase (MGMT) repair activity. Severa...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Duke University Press
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2718956/ https://ncbi.nlm.nih.gov/pubmed/18812520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2008-080 |
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