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KEY RESIDUES CONTROLLING PHENACETIN METABOLISM BY HUMAN CYTOCHROME P450 2A ENZYMES(†)

Cytochrome P450s (CYP) metabolize a large number of diverse substrates with specific regio- and stereo-specificity. A number of compounds, including nicotine, cotinine, and aflatoxin B(1), are metabolites of the 94% identical CYP2A13 and CYP2A6 enzymes but at different rates. Phenacetin and 4-aminob...

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Autors principals: DeVore, Natasha M., Smith, Brian D., Urban, Michael J., Scott, Emily E.
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718693/
https://ncbi.nlm.nih.gov/pubmed/18779312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.023770
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