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KEY RESIDUES CONTROLLING PHENACETIN METABOLISM BY HUMAN CYTOCHROME P450 2A ENZYMES(†)
Cytochrome P450s (CYP) metabolize a large number of diverse substrates with specific regio- and stereo-specificity. A number of compounds, including nicotine, cotinine, and aflatoxin B(1), are metabolites of the 94% identical CYP2A13 and CYP2A6 enzymes but at different rates. Phenacetin and 4-aminob...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2718693/ https://ncbi.nlm.nih.gov/pubmed/18779312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.023770 |
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