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CYTOCHROME P450 17A1 STRUCTURES WITH PROSTATE CANCER DRUGS ABIRATERONE AND TOK-001

Cytochrome P450 17A1 (P450c17) catalyzes the biosynthesis of androgens in humans(1). Since prostate cancer cells proliferate in response to androgen steroids(2,3), CYP17A1 inhibition is a new strategy to prevent androgen synthesis and treat lethal metastatic castration-resistant prostate cancer(4),...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: DeVore, Natasha M., Scott, Emily E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271139/
https://ncbi.nlm.nih.gov/pubmed/22266943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10743
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