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Key Residues Controlling Binding of Diverse Ligands to Human Cytochrome P450 2A Enzymes
Although the human lung cytochrome P450 2A13 (CYP2A13) and its liver counterpart cytochrome P450 2A6 (CYP2A6) are 94% identical in amino acid sequence, they metabolize a number of substrates with substantially different efficiencies. To determine differences in binding for a diverse set of cytochrom...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Pharmacology and Experimental Therapeutics
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2683692/ https://ncbi.nlm.nih.gov/pubmed/19251817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.109.026765 |
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