Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941

The phosphatidylinositide 3-kinase pathway is frequently deregulated in human cancers and inhibitors offer considerable therapeutic potential. We previously described the promising tricyclic pyridofuropyrimidine lead and chemical tool compound PI-103. We now report the properties of the pharmaceutic...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Raynaud, Florence I., Eccles, Suzanne A., Patel, Sonal, Alix, Sonia, Box, Gary, Chuckowree, Irina, Folkes, Adrian, Gowan, Sharon, De Haven Brandon, Alexis, Di Stefano, Francesca, Hayes, Angela, Henley, Alan T., Lensun, Letitia, Pergl-Wilson, Giles, Robson, Anthony, Saghir, Nahid, Zhyvoloup, Alexander, McDonald, Edward, Sheldrake, Peter, Shuttleworth, Stephen, Valenti, Melanie, Wan, Nan Chi, Clarke, Paul A., Workman, Paul
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2009
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718129/
https://ncbi.nlm.nih.gov/pubmed/19584227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-1200
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