The PI3K inhibitor GDC-0941 displays promising in vitro and in vivo efficacy for targeted medulloblastoma therapy

Deregulation of the Phosphoinositide 3-kinase (PI3K)/AKT signalling network is a hallmark of oncogenesis. Also medulloblastoma, the most common malignant brain tumor in children, is characterized by high levels of AKT phosphorylation and activated PI3K signalling in medulloblastoma is associated wit...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ehrhardt, Michael, Craveiro, Rogerio B., Holst, Martin I., Pietsch, Torsten, Dilloo, Dagmar
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4359256/
https://ncbi.nlm.nih.gov/pubmed/25596739
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