Agitation and High Ionic Strength Induce Amyloidogenesis of a Folded PDZ Domain in Native Conditions

Amyloid fibril formation is a distinctive hallmark of a number of degenerative diseases. In this process, protein monomers self-assemble to form insoluble structures that are generally referred to as amyloid fibrils. We have induced in vitro amyloid fibril formation of a PDZ domain by combining mech...

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Main Authors: Sicorello, Alessandro, Torrassa, Silvia, Soldi, Gemma, Gianni, Stefano, Travaglini-Allocatelli, Carlo, Taddei, Niccolò, Relini, Annalisa, Chiti, Fabrizio
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2009
Assuntos:
Protein
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717264/
https://ncbi.nlm.nih.gov/pubmed/19289055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.11.042
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