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Agitation and High Ionic Strength Induce Amyloidogenesis of a Folded PDZ Domain in Native Conditions
Amyloid fibril formation is a distinctive hallmark of a number of degenerative diseases. In this process, protein monomers self-assemble to form insoluble structures that are generally referred to as amyloid fibrils. We have induced in vitro amyloid fibril formation of a PDZ domain by combining mech...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Biophysical Society
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2717264/ https://ncbi.nlm.nih.gov/pubmed/19289055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.11.042 |
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