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Replica Exchange Simulations of the Thermodynamics of Aβ Fibril Growth

Replica exchange molecular dynamics and an all-atom implicit solvent model are used to probe the thermodynamics of deposition of Alzheimer's Aβ monomers on preformed amyloid fibrils. Consistent with the experiments, two deposition stages have been identified. The docking stage occurs over a wid...

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Bibliografiska uppgifter
Huvudupphovsmän: Takeda, Takako, Klimov, Dmitri K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Biophysical Society 2009
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716483/
https://ncbi.nlm.nih.gov/pubmed/19167295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.10.008
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