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Replica Exchange Simulations of the Thermodynamics of Aβ Fibril Growth

Replica exchange molecular dynamics and an all-atom implicit solvent model are used to probe the thermodynamics of deposition of Alzheimer's Aβ monomers on preformed amyloid fibrils. Consistent with the experiments, two deposition stages have been identified. The docking stage occurs over a wid...

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Bibliografiske detaljer
Main Authors: Takeda, Takako, Klimov, Dmitri K.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716483/
https://ncbi.nlm.nih.gov/pubmed/19167295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.10.008
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