Llwytho...

Temperature-Induced Dissociation of Aβ Monomers from Amyloid Fibril

Using all-atom molecular dynamics, we study the temperature-induced dissociation of Aβ monomers from the fibril protofilament. To accelerate conformational sampling, simulations are performed at elevated temperatures and peptide concentrations. By computing free energy disconnectivity graphs we mapp...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Takeda, Takako, Klimov, Dmitri K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Biophysical Society 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483770/
https://ncbi.nlm.nih.gov/pubmed/18502791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.131698
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