Temperature-Induced Dissociation of Aβ Monomers from Amyloid Fibril

Using all-atom molecular dynamics, we study the temperature-induced dissociation of Aβ monomers from the fibril protofilament. To accelerate conformational sampling, simulations are performed at elevated temperatures and peptide concentrations. By computing free energy disconnectivity graphs we mapp...

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Bibliographic Details
Main Authors: Takeda, Takako, Klimov, Dmitri K.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2008
Subjects:
Biophysical Theory and Modeling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483770/
https://ncbi.nlm.nih.gov/pubmed/18502791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.131698
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