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Replica exchange molecular dynamics of the thermodynamics of fibril growth of Alzheimer's Aβ(42) peptide

The growth of amyloid fibrils is studied by replica exchange molecular dynamics in an implicit solvent. Our data indicate that extremely long simulation times (at least a few hundred ns) are necessary to study the thermodynamics of fibril elongation in detail. However some aspects of the aggregation...

詳細記述

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書誌詳細
主要な著者: Han, Ming, Hansmann, Ulrich H. E.
フォーマット: Artigo
言語:Inglês
出版事項: American Institute of Physics 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166336/
https://ncbi.nlm.nih.gov/pubmed/21842950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.3617250
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