CD4+CD25− T cells transduced to express MHC class I-restricted epitope specific TCR synthesize Th1 cytokines and exhibit MHC class I-restricted cytolytic effector function in a human melanoma model

Cytolytic T cell-centric active specific and adoptive immunotherapeutic approaches might benefit from the simultaneous engagement of CD4+ T cells. Considering the difficulties in simultaneously engaging CD4+ and CD8+ T cells in tumor immunotherapy -- especially in an antigen specific manner -- “redi...

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Bibliographische Detailangaben
Hauptverfasser: Chhabra, Arvind, Yang, Lili, Wang, Pin, Comin-Anduix, Begoña, Das, Raja, Chakraborty, Nitya G., Ray, Swagatam, Mehrotra, Shikhar, Yang, Haiguang, Hardee, Cinnamon L., Hollis, Roger, Dorsky, David I., Koya, Richard, Kohn, Donald B., Ribas, Antoni, Economou, James S., Baltimore, David, Mukherji, Bijay
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715965/
https://ncbi.nlm.nih.gov/pubmed/18606658
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