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Probing the role of the cation–π interaction in the binding sites of GPCRs using unnatural amino acids
We describe a general application of the nonsense suppression methodology for unnatural amino acid incorporation to probe drug–receptor interactions in functional G protein-coupled receptors (GPCRs), evaluating the binding sites of both the M2 muscarinic acetylcholine receptor and the D2 dopamine re...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2715518/ https://ncbi.nlm.nih.gov/pubmed/19581583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903260106 |
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