A Cation-π Interaction in the Binding Site of the Glycine Receptor Is Mediated by a Phenylalanine Residue

Cys-loop receptor binding sites characteristically contain many aromatic amino acids. In nicotinic ACh and 5-HT(3) receptors, a Trp residue forms a cation-π interaction with the agonist, whereas in GABA(A) receptors, a Tyr performs this role. The glycine receptor binding site, however, contains pred...

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Hauptverfasser: Pless, Stephan A., Millen, Kat S., Hanek, Ariele P., Lynch, Joseph W., Lester, Henry A., Lummis, Sarah C. R., Dougherty, Dennis A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2008
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649377/
https://ncbi.nlm.nih.gov/pubmed/18945901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2540-08.2008
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