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Two Amino Acid Residues Contribute to a Cation-π Binding Interaction in the Binding Site of an Insect GABA Receptor

Cys-loop receptor binding sites characteristically possess an “aromatic box,” where several aromatic amino acid residues surround the bound ligand. A cation-π interaction between one of these residues and the natural agonist is common, although the residue type and location are not conserved. Even i...

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Autors principals: Lummis, Sarah C. R., McGonigle, Ian, Ashby, Jamie A., Dougherty, Dennis A.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233689/
https://ncbi.nlm.nih.gov/pubmed/21865479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1610-11.2011
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