GABA Binding to an Insect GABA Receptor: A Molecular Dynamics and Mutagenesis Study

RDL receptors are GABA-activated inhibitory Cys-loop receptors found throughout the insect CNS. They are a key target for insecticides. Here, we characterize the GABA binding site in RDL receptors using computational and electrophysiological techniques. A homology model of the extracellular domain o...

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Detalhes bibliográficos
Main Authors: Ashby, Jamie A., McGonigle, Ian V., Price, Kerry L., Cohen, Netta, Comitani, Federico, Dougherty, Dennis A., Molteni, Carla, Lummis, Sarah C.R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2012
Assuntos:
Cell Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3512037/
https://ncbi.nlm.nih.gov/pubmed/23200041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.10.016
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