Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1

Metastatic tumors can prepare a distant site for colonization via the secretion of factors that act in a systemic manner. We hypothesized that non- or weakly metastatic human tumor cells may act in an opposite fashion by creating a microenvironment in distant tissues that is refractory to colonizati...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Kang, Soo-Young, Halvorsen, Ole J., Gravdal, Karsten, Bhattacharya, Nandita, Lee, Jung Min, Liu, Nathan W., Johnston, Brian T., Johnston, Adam B., Haukaas, Svein A., Aamodt, Kristie, Yoo, Sun, Akslen, Lars A., Watnick, Randolph S.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2009
विषय:
Biological Sciences
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715504/
https://ncbi.nlm.nih.gov/pubmed/19581582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903120106
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